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Budi Utomo
Environmental Health Department, Polytechnic Health Ministry of Semarang
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Journal : Journal of Islamic Medicine

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Antioxidant and Cytotoxic Effect of Water Extract of Ananas comosus in Human Breast Cancer Cell Line Widyanto, Rahma Micho; Halimah, Ririt Nafi'; Rahmi, Yosfi; Utomo, Budi; Proborini, Wahyu Diah; Yunimar, Yunimar
Journal of Islamic Medicine Vol 4, No 2 (2020): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2020
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v4i2.10109

Abstract

Background: Breast cancer is the most common type of cancer and the second leading cause of death in the world. One of the supporting therapeutic efforts to overcome cancer is through food, mainly fruits. Ananas comosus has been investigated for its potential as an anti-cancer. It is a source of antioxidants from the content of Vitamin C and flavonoids that work by capturing free radicals, resulting in inhibition of cancer cell proliferation.Objective :This study was conducted to determine the antioxidant activity and cytotoxicity of water extract of Ananas comosus on T-47D breast cancer cell lines.Method: The process of extracting pineapple flesh is done using water as a solvent, then tested its antioxidant activity using DPPH and cytotoxicity using MTT assay on T-47D.Result: IC50 value for antioxidant activity was 463.369 μg / mL and the IC50 for the cytotoxicity assay was 488.003 μg / mL.Conclusion : The water extract of Ananas comosus have very weak antioxidant activity and moderate cytotoxicity properties that have potential as chemo preventive agents in T-47D breast cancer cell lines.
Co-Authors A.A. Ketut Agung Cahyawan W Achmad Ardianto, Achmad Achmad Basori, Achmad Achmad Basuki Adiana Mutamsari Witaningrum Afifah, Alvira Nadya Nur Afifuddin Dalimunthe, Afifuddin Agus F, Agus Agus Setiya Budi, Agus Setiya Anak Agung Istri Sri Wiadnyani Ardi Wijana, I Putu Agung Arif Budi Wibowo, Arif Budi Arwin A.P. Akip, Arwin A.P. Aziz, Moh. Nurul Cokorda Istri Raka Marsiti Damiati - Eddy Bagus Wasito Eko Supriyanto Endang L. Achadi, Endang Fathmawati Fathmawati Gusti Zulkifli Mulki Halimah, Ririt Nafi' Heny Arwati Hervi, Navis Irwanto Irwanto Isnaeni Isnaeni Iwan Iwan Juniastuti Juniastuti Kameo, Yopi I Kartuti Debora, Kartuti Khairul Bariyah, Khairul Kuswanto Nurhadi, Kuswanto M. Qushay, M. Majematang Mading Marheni Marheni Maria Inge Lusida Meta Indah Fitriani Muhammad Husni Muhammad Kazwaini Nasronudin Nasronudin Nazarudin, Kemal Nugroho, Agung Pangestu Perwira, Eka Perwira, Eka Polewangi, Yudi Daeng Pramanto, Aris Cholid Baicuni Prihartini Widiyanti Proborini, Wahyu Diah Pujianto Pujianto Puspaningtyas, Pramita R Irawati Ismail, R Irawati Rahma Micho Widyanto Retno Pudji Rahayu Rin Widya Agustin S. Prawirodigdo Sabarinah Sabarinah, Sabarinah Salmah Lilik Samuel Febriary Khristyson Selviana Selviana Siti Qamariyah Khairunisa, Siti Qamariyah Sofiana, Ayu Ismoyo Solichin Solichin Subagyo Yotopranoto Subakti, Muhammad Sudarto Sudarto Suhintam Pusarawati Sulaiman Sulaiman Sulastoro, Sulastoro Sunarno Ranu Widjojo, Sunarno Ranu Supriyanto Supriyanto Surilena Hasan Tandjung, Kasmir Tomohiro Kotaki, Tomohiro Ulin Nuschati Ummah, Fatayah Nadhlastul Wafrotur Rohmah Widyaratri, Yuni Yasir Arafat, Yasir Yosfi Rahmi Yudhyarto, Bima Yuniawan, Farah Shabrina Amazida YUNIMAR YUNIMAR Zubairi Djoerban